Which of the following is a symptom of digoxin toxicity?

• A. Confusion
• B. Weight loss
• C. Hives
• D. Cough

Answer: (A)

Digoxin toxicity often manifests with neurological effects, and confusion is a common CNS sign, especially in older adults. While other symptoms like nausea, vomiting, loss of appetite, or visual changes can occur, confusion directly reflects the brain’s response to the drug’s toxic effects. The other options don’t fit with digoxin toxicity: hives would suggest an allergic reaction, cough isn’t a typical feature of digoxin poisoning, and weight loss is not a hallmark sign. If confusion arises in a patient taking digoxin, it’s important to consider elevated digoxin levels and evaluate renal function and electrolytes, since impaired clearance and electrolyte disturbances raise the risk of toxicity.