Which neurologic symptom could indicate thujone exposure?

• A. Tremors and seizures
• B. Rash and itching
• C. Shortness of breath
• D. Constipation

Answer: (A)

Thujone exposure tends to cause central nervous system stimulation. It acts as a GABA-A receptor antagonist, which blocks inhibitory signals in the brain and leads to increased neuronal firing. That disinhibition can produce motor hyperactivity, presenting as tremors and, with greater exposure, seizures. So tremors and seizures are the neurologic signs most consistent with thujone toxicity.

Rash and itching point to a skin reaction rather than a neurologic effect. Shortness of breath suggests respiratory or cardiovascular involvement, not a primary neurotoxic effect. Constipation is a gastrointestinal effect and not a primary neurologic symptom.